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apap tramadol To illustrate, a grain-of-salt report that I carry a faulty gene raising my risk of Alzheimer's may spur me onto requesting an expensive follow-up diagnostic test, even though current evidence linking single genetic sequence mutations to disease development is largely lackluster. As a medical student, I know firsthand how difficult it is for clinicians to turn down these requests ??? the personal, professional, and legal risks of being wrong make this all but impossible.